Abstract: Fatigue In Adult Coeliac Disease
Abstract: Fatigue In Adult Coeliac Disease.
Aliment Pharmacol Ther. 2005 Sep 1;22(5):489-94. Related Articles,
Siniscalchi M, Iovino P, Tortora R, Forestiero S, Somma A, Capuano
L, Franzese MD, Sabbatini F, Ciacci C.
Gastrointestinal Unit, Department of Clinical and Experimental
Medicine, Federico II University of Naples, Italy.
Background : Fatigue is reported by many adults
at the moment of diagnosis of coeliac disease and during follow-up.
Aim : To evaluate the prevalence, characteristics
and associations of fatigue in adult coeliac disease patients.
Methods : The investigated sample comprised adults
from Campania, Italy.
A total of 130 coeliac disease patients were consecutively recruited
in both treated (59 on gluten-free diet) and untreated conditions
(71 on normal diet).
The control group was made up of 80 healthy controls.
Coeliac disease patients and healthy controls underwent laboratory
tests, a set of questionnaires for studying fatigue: visual analogue
scale for fatigue, chronic fatigue syndrome questionnaire, fatigue
severity scale and a modified version of the Zung self-rating depression
Results : Coeliac disease patients showed a significantly
lower body mass index than controls (P = 0.0001), lower serum iron
(P = 0.04).
The entire cohort of coeliac disease patients reported greater
modified version of the Zung self-rating depression scale score
(P = 0.001), greater visual analogue scale for fatigue score (P
= 0.0001) and greater chronic fatigue syndrome questionnaire score
(P = 0.0001) compared with healthy controls.
Coeliac disease patients on a gluten-free diet had a significantly
higher modified version of the Zung self-rating depression scale
score than coeliacs on a normal diet (P = 0.001).
The prevalence of pathological modified version of the Zung self-rating
depression scale score was 17% in all coeliac disease patients and
0% in healthy controls.
A significant correlation was found between modified version of
the Zung self-rating depression scale score and fatigue scale scores
in coeliacs on a normal diet.
Presence/absence of gastrointestinal symptoms did not show any
significant correlation with modified version of the Zung self-rating
depression scale score and fatigue scale scores.
In coeliacs on a gluten-free diet, modified version of the Zung
self-rating depression scale and fatigue scales scores did not significantly
differ from coeliacs on a normal diet and were not related to dietetic
Conclusion : In coeliacs, fatigue is a common
finding, which ameliorates with the gluten-free diet and is strictly
correlated to depression although coeliacs on a gluten-free diet
showed more frequent and more severe depression symptoms than coeliacs
on a normal diet.
Source: PMID: 16128688 [PubMed - in process]
Category: Fatigue in adult coeliac disease, Siniscalchi, Iovino,
Tortora, Forestiero, Somma, Capuano, Franzese, Sabbatini, Ciacci
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